Preparation and Characterization of Transdermal Therapeutic System Containing Simvastatin: A Statistical Study

Abstract: Introduction: The purpose of the present study was to design, develop, and characterize transdermal patches containing Simvastatin for management blood lipid levels. Materials Methods: Transdermal were prepared by solvent casting method. evaluated physicochemical characteristics such as thickness, weight variation, folding endurance, percentage moisture uptake, content, drug ex-vivo permeation study. Eudragit polymer grades ERL100 ERS100 used in 6:4 8:2 ratio prepare formulations. Formulations using 23 factorial designs. Stability studies films subjected environmental conditions at a temperature 45°C, 75% relative humidity 45 days. Results: parameters like flux, amount permeated, permeability coefficient obtained. It found that all these values highest formulation F8. Conclusion: Based on parameters, F8 considered best formulation. Key words: patches, Simvastatin, Factorial designs, Matrix, Eudragit.